How Systemic Enzymes Fight for Your Brain Health

systemic enzymes brain

Your body requires millions of biochemical reactions to keep you alive day-in and day-out. These reactions wouldn’t be possible without enzymes, which can perform up to several million catalytic reactions per second.[i]

The enzymes work by speeding up these biochemical reactions significantly – keeping a pace that’s fast enough for your very survival.

While your body does manufacture enzymes (trillions of them), this manufacture slows down with age, declining at a rate of up to 13 percent per decade after you reach puberty. Eventually, you will likely reach a state of enzyme deficiency, and this time may coincide with many symptoms and conditions blamed on “aging.”

Among them, declining brain health, forgetfulness and even dementia including Alzheimer’s disease may be influenced by a lack of the crucial catalysts, enzymes, your body needs for survival.

What Causes Dementia?

There are more than 35 million people worldwide struggling with dementia, and this number is expected to double by 2030 and more than triple by 2050.[ii] The most common form of dementia is Alzheimer’s disease, a degenerative brain disorder that affects your memory, behavior, cognitive function and ability to carry out daily activities.

It’s thought that Alzheimer’s disease results from a combination of genetic, lifestyle and environmental factors. Your diet is thought to play a role, as does your age and, likely, exposure to toxins such as heavy metals.

People with Alzheimer’s disease typically show two types of abnormalities in their brains:[iii]

  • Plaques, which are clumps of beta-amyloid protein that damage and destroy brain cells
  • Tangles, which are abnormal tangles of tau protein that cause a failure in your brain’s transport system (this carries nutrients and other materials between brain cells)

In short, brain damage from Alzheimer’s disease appears to be caused by the development of abnormal fibrous protein clumps called amyloid plaques, tangled bundles of fibers called neurofibrillary tangles and the resulting loss of connections between neurons in the brain.

Enzymes May Help Break Down Amyloid Plaques

Research by the Mayo Clinic revealed an enzyme known as BACE2 destroys beta-amyloid protein, which makes up toxic beta-amyloid plaques. According to the study, published in Molecular Neurodegeneration:[iv]

“Based on its high catalytic efficiency, its ability to degrade Aß [amyloid ß-protein] intracellularly, and other characteristics, BACE2 represents a particularly strong therapeutic candidate for the treatment or prevention of AD.”

Nattokinase, an enzyme extracted from a specially fermented soy, has also been found to degrade amyloid fibrils that form deposits in the brains of people with Alzheimer’s disease.[v] Researchers noted:[vi]

“The discovery of an enzyme which can be safely taken orally and can degrade amyloid fibrils could be very useful in the therapy of amyloid-related diseases.”

If You Have Hardening of Your Arteries, You’re More Likely to Have Plaques in Your Brain

The health of your heart is intricately interwoven with that of your brain. Recent research revealed, for instance, that people with hardening of their arteries (and high blood pressure) were more likely to have brain plaques associated with Alzheimer’s disease.[vii]

Specifically, for each unit increase in arterial stiffness, people in their 80s were twice as likely to have beta-amyloid plaques in their brain. The study’s lead author noted:[viii]

“This is more evidence that cardiovascular health leads to a healthy brain.”

Chronic inflammation — the result of many years of poor diet, inactivity, excess alcohol, cigarette smoking, excessive stress and other unhealthy lifestyle — causes a buildup of arterial plaque inside your arteries, narrowing the channel for blood to flow through and spiking your blood pressure.

These arterial plaques secretly lining your veins and clogging your arteries are made of fats and cholesterols held together by a fibrin mesh. Fibrin is a protein used to repair wounds, deposited while the area remains in an inflammatory state – your body’s natural response to injury, making chronic inflammation a leading risk factor for heart disease.

Maintaining high levels of proteolytic enzymes throughout your body is absolutely critical for your cardiovascular health. They not only help prevent arterial plaque from forming by putting the brakes on runaway chronic inflammation, they also help remove plaque that has already accumulated by breaking down the fibrin mesh holding the plaque together.

Fibrin is a protein and proteolytic enzymes are proteases – the type of enzymes that break down proteins. Proteolytic enzymes dissolve the actual fibrin bonds holding arterial plaque together so it can be safely whisked away for disposal.

Yet, Alzheimer’s disease is also thought to be worsened or triggered by chronic inflammation, which is known to increase the generation of amyloid-beta protein.[ix] This suggests that fighting chronic inflammation with systemic enzymes might not only be beneficial to your heart … but to your brain as well.

Systemic Enzyme Therapy for Your Brain Health

Both digestive and systemic enzyme therapies may help prevent and lessen the impact of Alzheimer’s disease. Digestive enzyme therapy can support the absorption of vitamins and minerals for improved nerve communication while supplementing with systemic proteolytic enzymes, which enter your bloodstream and travel throughout your body, may help remove heavy metals, reduce inflammation and break down excess fibrin. As reported by Michael Sellar, editor of Enzyme Digest:[x]

“Systemic enzyme therapy (SET) refers to enzymes taken by mouth on an empty stomach, which, after absorption, flow throughout the body to wherever they are needed. These make up the metabolic shortfall directly.”

Remember, proteolytic enzymes are naturally produced in your pancreas, but your natural production declines with age.[xi] Hydrochloric acid in your stomach is also reduced with age, and this is another variable, as hydrochloric acid plays a role in activating enzymes.

So what can you do? It’s important to include raw foods in your diet to help replenish some of your body’s enzyme stores naturally, however for therapeutic effects you’re going to want Heal-n-Soothe, the best systemic enzyme formula to replenish your body’s supply of vital enzymes (now with double the enzymes).

systemic enzymes brain


[i] Wikibooks Biochemistry/Catalysis

[ii] World Health Organization April 2012

[iii] Mayo Clinic, Alzheimer’s Disease Causes

[iv] Mol Neurodegener. 2012 Sep 17;7:46.

[v] J Agric Food Chem. 2009 Jan 28;57(2):503-8.

[vi] NutraIngredients February 16, 2009

[vii] Neurology. 2013 Nov 5;81(19):1711-8.

[viii] WebMD October 16, 2013

[ix] Journal of Neuroinflammation 2014, 11:25 

[x] PositiveHealthOnline December 2001

[xi] Digestion. 1991;50(3-4):202-11.

Filed Under: Alzheimer's
Written By:  Updated:
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Jesse Cannone, CFT, CPRS, MFT

Jesse is the co-founder and visionary CEO of The Healthy Back Institute®, the world-leading source of natural back pain solutions. His mission as a former back pain sufferer is to help others live pain free without surgery and pharmaceuticals.

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19 thoughts on “How Systemic Enzymes Fight for Your Brain Health”

  1. gavin hitch says:

    I have spent over $100,000 to try to cure my wife’s dementia.I don’t believe heal-n-soothe will cure it I know it has been the best supplement by a million miles.I have used the product off and on for 12 months on my wife.The improvements have been amazing.My wife has vascular dementia.She has been in care twice, no alternative supplements,the pharmacuticals have been mind destroying at best.After two week’s home back on heal-n-soothe she is back to basic language.As an ex nurse with severe back problens this product has done more than any drug to stop the pain.Now I know it may not work for every one but it would be my first choice and now it’s my only choice.

    1. Steve says:

      Gavin, That is great to hear, and another first for the use of Heal n Soothe…

      Can you tell us the daily dose she is taking?


    2. Jacqueline says:

      Amazing!! I suffer from joint pain (RA)especially on my hands n Im a driver too but after taking soothe n heal the maximum dose the pain went away after 1day n thats a big deal because I thought Id have to change job.

      1. Admin says:

        Hi Jacqueline,
        Thank you so much for taking the time to leave your feedback. It is so great to hear you are doing so well with Heal-n-Soothe!

        Do please contact us if you feel you need any further advice at any time

        Our Very Best Wishes
        Admin(The Healthy Back Institute)

  2. Leigh Stebbins says:

    As I suffer from Muscular, Nerve and Skeletal Pain this information has been a God Send and has helped to give Me a much better quality of Life and hope for a greater Future.

    1. Kay says:

      Have had over 20 surgeries from car accident years ago – chronic pain in back, knees, feet. Heal-n-Soothe has helped so much. Take 4 in morning on empty stomach 1 hour before breakfast and try to remember 3-4 in the evening too.
      I am pleased with reduced inflammation and less pain, and avoid pain meds as much as possible.

  3. Donna Hubbard says:

    Very factual and well referenced article. It answers many questions with needed details. I like that you associate heart health with inflammation, instead of just plaque, and that you emphasize the need for raw foods as well as supplements. I am 79 and will certainly add your suggestions to my daily routine as soon as my extremely limited budget will allow it. Thank you for this information.

  4. Janet Baloga says:

    Yes, I have taken Heal and Soothe for 4 years or so, now, and absolutely love the stuff. I don’t know what I’d do without it.
    Thanks, Jessie
    Janet Baloga

  5. Michael W Mowery says:

    What are your results and/or feedback regarding rheumatoid arthritis? I’ve read a lot about generalized arthritis, but I’m interested in more detailed info with the above question. I thank you for your time!

  6. Admin says:

    Hi Michael,

    Thank You for your question. Please take a look at our book “Arthritis Reversed” which we hope will be helpful to you. All details about the book are available via the link below

    Thank you
    Admin (The Healthy Back Institute)

  7. Treva Richter says:

    I have only been taking the heal-n-soothe and joint support for 3 days and I really believe it is making a difference. I am less stiff in the mornings and seem to be experiencing less pain. (Am I dreaming?) I take many supplements so I am hoping that I can narrow them down taking these. Do these really work that fast and will it keep getting better as I take them??

  8. Verna -Konrad Marilyn says:

    The best information I have read to date. Backed up by amazing research going on in vascular dementia which is a long read but worth the time backed up with reference resource . Impressive to say the least I had to share !

  9. Verna -Konrad Marilyn says:

    Please make time for this site. So many subjects covered impressive back up !

  10. carolyn watson says:

    Three of my four sons have Gout since the age of 26 and are now 48 and 51 years. My one son is going to a specialist because he is allergic to the medication and just recently after 22 years have a medication that is controlling his uric acid levels. I am now taking heal-n-soothe and have talked to him about this. Would he continue to take the pharmaceutical meds as well as heal-n-soothe. He cannot take the chance of attacks occurring as he is quite crippled and cannot work.

  11. Steve HBI-Staff says:

    Carolyn, Based on what you have indicated, we have to suggest you consult your son’s physicians before they start taking the product…

    That said, our protocol regarding taking pharmaceuticals and supplements is to wait 60 min between taking both them…



  12. Bruce says:

    what if anything does the product do for arthritis inflamation

    1. Admin says:

      HI Bruce,
      Thank you for your question. Arthritis is inflammation of the joints – and proteolytic systemic enzymes are a powerful natural anti-inflammatory. Most inflammatory conditions could benefit from taking a proteolytic enzyme supplement. Other ingredients in Heal-n-Soothe® also help arthritis sufferers.

      You can learn much more on our website. Here are a couple articles to get you started:

      Thank you , Our Best Wishes
      Admin (The Healthy Back Institute)

  13. Gary Mann says:

    due to arthritis, my orthopedic surgeon said, I have had my right knee scoped twice and still have severe pain in both knees.

  14. Steve HBI_Staff says:

    Gary, Please read this special report as it will help you understand your condition from another point of view



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