You can switch the location at any time even during a session without reducing the effect. (before you disconnect your self please pause the device)
If your wrist gets sore, you can put the straps around your ankles.
If you can not use the straps anymore you can switch to the sticky electros and you can put them anywhere (except on the face or genitals). For whole body results, it is best to put one electrode on one side of the body and the second electrode on the other side of the body.